| ncRNA name | hsa-miR-106a |
| ncRNA Category | miRNA |
| Disease name | retinopathy of prematurity (ROP) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line Y79 |
| Methods | qPCR, luciferase reporter assay, transfection |
| Expression pattern | down-regulated |
| Functional description | We evaluated the in vivo expression profile of the miR-17 family in the murine retinopathy of prematurity (ROP) model, whereby Vegfa expression is highly enhanced at the early stage of retinal neovascularization, and we found simultaneous reduction of all miR-17 family members at this stage. We observed binding of these miRs to specific sites in the 3' UTRs of Hif1a and Vegfa. |
| PubMed ID | 25775553 |
| Year | 2015 |
| Title | Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch. |
| Drug-related ncRNA | NO |
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